Kameyama S, Tanaka R, Honda Y, Hasegawa A, Yamazaki H, Kawaguchi T
Department of Neurosurgery, Niigata University, Japan.
Acta Neurochir (Wien). 1994;129(3-4):127-30. doi: 10.1007/BF01406491.
The growth rate of 19 residual acoustic neurinomas was examined in a long-term follow-up study (median, 10 years; range, 5 to 17 years) following intracapsular removal. Of these, 10 (53%) had regrowth, three (16%) showed regression, and six (32%) were unchanged. The 10 acoustic neurinomas showing regrowth were divided into two categories, either solid or cystic, according to computed tomographic findings. Five acoustic neurinomas with cyst formation showed rapid regrowth, with the tumour doubling time ranging from 0.15 to 5.0 years (median, 4.5 years), and required re-operation. Five solid tumours showed slow regrowth, with the tumour doubling time ranging from 9 to 34 years (median, 15 years). Although cyst formation is a major factor in rapid regrowth, residual acoustic neurinomas without cyst formation have a slower growth potential. In this study, 74% of the residual acoustic neurinomas have never required re-operation. It is advisable to choose intracapsular removal if there is major risk of neurological deficits.
在一项长期随访研究（中位数为10年；范围为5至17年）中，对19例经囊内切除术后残留的听神经瘤的生长速率进行了检查。其中，10例（53%）出现了肿瘤再生长，3例（16%）显示肿瘤缩小，6例（32%）保持不变。根据计算机断层扫描结果，10例出现肿瘤再生长的听神经瘤被分为实性或囊性两类。5例形成囊肿的听神经瘤出现快速再生长，肿瘤倍增时间为0.15至5.0年（中位数为4.5年），需要再次手术。5例实性肿瘤生长缓慢，肿瘤倍增时间为9至34年（中位数为15年）。虽然囊肿形成是快速再生长的主要因素，但未形成囊肿的残留听神经瘤生长潜力较低。在本研究中，74%的残留听神经瘤从未需要再次手术。如果存在严重神经功能缺损风险，建议选择囊内切除术。
