Harrison K J, Massing B, McKenna C, Kalousek D K
Department of Cytogenetics, Toronto Hospital, Ontario, Canada.
Am J Hematol. 1995 Feb;48(2):88-91. doi: 10.1002/ajh.2830480204.
Monosomy 7 is a non-random cytogenetic abnormality that is frequently associated with myelodysplastic syndromes (MDS). Twenty-four bone marrow samples from five pediatric patients with MDS were analysed using both traditional and interphase cytogenetic analysis. The majority of the metaphases were monosomic for chromosome 7 while interphase cytogenetic analysis consistently detected a disomic cell population in nondividing cell populations. This suggests that the monosomy 7 cells have a distinct proliferative advantage compared to the disomic cell population. The results demonstrate that interphase cytogenetic analysis provides important cytogenetic information about non-dividing cell subpopulations, enhancing our understanding of the cell dynamics of normal and monosomy 7 cells in MDS.
单体7是一种非随机性细胞遗传学异常，常与骨髓增生异常综合征（MDS）相关。使用传统和间期细胞遗传学分析方法，对来自5名患有MDS的儿科患者的24份骨髓样本进行了分析。大多数中期细胞为7号染色体单体，而间期细胞遗传学分析在非分裂细胞群体中始终检测到二倍体细胞群体。这表明与二倍体细胞群体相比，单体7细胞具有明显的增殖优势。结果表明，间期细胞遗传学分析为非分裂细胞亚群提供了重要的细胞遗传学信息，增强了我们对MDS中正常细胞和单体7细胞的细胞动力学的理解。
