Bonnaud G, Cadiot G, Mignon M
Service de Gastro-entérologie, CHU Bichat-Claude-Bernard, Paris.
Ann Chir. 1994;48(6):535-46.
The current strategy recommended for Zollinger-Ellison syndrome (ZES) has significantly improved the outcome of this condition. Diagnosis is based on determinations of basal and post-secretin gastric acid output and serum gastrin levels. A crucial step is differentiation of patients with sporadic ZES from those with multiple endocrine neoplasia type 1 syndrome. Only the former should undergo excision of the tumor when feasible. All available imaging techniques should be used pre- and intra-operatively to detect tumorous lesions. Exploratory laparatomy is warranted in patients who have sporadic ZES without evidence of liver metastases.
目前针对卓-艾综合征（ZES）推荐的治疗策略已显著改善了该病的治疗效果。诊断基于基础胃酸分泌量和注射促胰液素后的胃酸分泌量以及血清胃泌素水平的测定。一个关键步骤是将散发性ZES患者与1型多发性内分泌肿瘤综合征患者区分开来。只有前者在可行时应进行肿瘤切除。术前和术中应使用所有可用的成像技术来检测肿瘤性病变。对于散发性ZES且无肝转移证据的患者，有必要进行剖腹探查术。
