大鼠中戈米辛A对早期3-甲基-4-二甲基氨基偶氮苯诱导的肝癌发生的抑制作用。
Inhibition of early 3-methyl-4-dimethylaminoazobenzene-induced hepatocarcinogenesis by gomisin A in rats.
作者信息
Nomura M, Ohtaki Y, Hida T, Aizawa T, Wakita H, Miyamoto K
机构信息
Research Laboratory for Development of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University, Tokyo, Japan.
出版信息
Anticancer Res. 1994 Sep-Oct;14(5A):1967-71.
The effects of gomisin A, a lignan component of Schizandra fruits, on hepatocarcinogenesis caused by 3'-methyl-4- dimethylaminoazobenzene (3'-MeDAB) in male Donryu rats were investigated. Gomisin A significantly inhibited the appearance of foci stained for glutathione S-transferase placental form (GST-P) in the liver of rats given feed with 0.06% 3'-MeDAB. Gomisin A (30 mg/kg/daily, po) decreased the concentration of 3'-MeDAB-related azo dyes in the liver, and increased their excretion in the bile. The ratio of diploid to tetraploid nuclei increased during ingestion of 3'-MeDAB, but gomisin A delayed the increase. After the withdrawal of 3'-MeDAB, carcinogen-related azo dyes were not detected in the liver or bile, but the proportion of diploid nuclei remained high, although it decreased with a 0.03% gomisin A diet. The results suggested that the effects of gomisin A are related to improved liver function and reversal of abnormal ploidization.
研究了五味子果实中的木脂素成分戈米辛A对雄性唐利大鼠由3'-甲基-4-二甲基氨基偶氮苯（3'-MeDAB）诱导的肝癌发生的影响。戈米辛A显著抑制了喂食含0.06% 3'-MeDAB饲料的大鼠肝脏中谷胱甘肽S-转移酶胎盘型（GST-P）染色灶的出现。戈米辛A（30毫克/千克/每日，口服）降低了肝脏中3'-MeDAB相关偶氮染料的浓度，并增加了其在胆汁中的排泄。在摄入3'-MeDAB期间，二倍体与四倍体核的比例增加，但戈米辛A延迟了这种增加。停用3'-MeDAB后，在肝脏或胆汁中未检测到致癌物相关偶氮染料，但二倍体核的比例仍然很高，尽管在含0.03%戈米辛A的饮食中该比例有所下降。结果表明，戈米辛A的作用与肝功能改善和异常倍性化的逆转有关。
Zotero 插件