五味子甲素（TJN-101）对肝脏再生的影响。

Effect of Gomisin A (TJN-101) on liver regeneration.

作者信息

Kubo S, Ohkura Y, Mizoguchi Y, Matsui-Yuasa I, Otani S, Morisawa S, Kinoshita H, Takeda S, Aburada M, Hosoya E

机构信息

Second Department of Surgery, Osaka City University Medical School, Japan.

出版信息

Planta Med. 1992 Dec;58(6):489-92. doi: 10.1055/s-2006-961532.

DOI:10.1055/s-2006-961532

PMID:1484885

Abstract

We studied the effect of TJN-101, a lignan component of Schisandra fruits (Schisandrae fructus), on liver regeneration after partial hepatectomy. TJN-101 was given orally to male Wistar rats 30 min before partial hepatectomy. The mitotic index and the level of DNA synthesis increased after partial hepatectomy and their increase was significantly enhanced by TJN-101. Ornithine decarboxylase (ODC) activity increased in the early stages of liver regeneration and it was also significantly enhanced by TJN-101. Besides, TJN-101 enhanced the increase in hepatic putrescine. These results suggest that TJN-101 stimulates liver regeneration after partial hepatectomy by enhancing ODC activity, which is an important biochemical event in the early stages of liver regeneration.

摘要

我们研究了五味子果实（五味子）中的木脂素成分TJN - 101对部分肝切除术后肝脏再生的影响。在部分肝切除术前30分钟给雄性Wistar大鼠口服TJN - 101。部分肝切除术后有丝分裂指数和DNA合成水平升高，且TJN - 101显著增强了它们的升高。鸟氨酸脱羧酶（ODC）活性在肝脏再生早期升高，TJN - 101也显著增强了这一活性。此外，TJN - 101增强了肝脏腐胺的增加。这些结果表明，TJN - 101通过增强ODC活性来刺激部分肝切除术后的肝脏再生，而ODC活性增强是肝脏再生早期的一个重要生化事件。