Bounhoure J P, Galinier M, Assoun B, Albenque J P, Doazan J P, Boubakar D
Service de cardiologie clinique et expérimentale, CHU Toulouse-Rangueil.
Arch Mal Coeur Vaiss. 1994 Apr;87(4):445-50.
This study was based on 42 cases of 2nd or 3rd degree atrioventricular block out of 292 cases of inferior wall myocardial infarction. The criteria of selection were monitoring in the intensive care unit during the acute phase, selective coronary angiography in the first 48 hours to 5 days, and regular clinical follow-up during the first year after infarction. The conduction defect was either immediately recorded on the first ECG, delayed (between the 12th and 24th hour) or late (after the 3rd day). These 42 inferior wall infarcts with atrioventricular block (incomplete in 14 and complete in 28 cases) differed from inferior infarction without block by: - the severity of the clinical signs during the acute phase (35% with cardiac failure, 19% with cardiogenic shock); - the severity of the coronary lesions (71.4% with triple vessel disease in infarction with atrioventricular block compared with 32% in those without block, p < 0.02); - the prevalence of the association of > 70% stenosis of the right coronary and left anterior descending arteries; - the alteration of left ventricular function (53% patients with atrioventricular block had ejection fraction of under 30%); - the severity of these infarcts was not related to the atrioventricular block which regressed in 95% of cases but to the severity of the coronary disease, the left ventricular dysfunction and the advanced age of the patients (72.3 +/- 8 years).
本研究基于292例下壁心肌梗死患者中的42例二度或三度房室传导阻滞病例。入选标准为急性期在重症监护病房进行监测、在最初48小时至5天内进行选择性冠状动脉造影以及在梗死后第一年进行定期临床随访。传导缺陷要么在首次心电图上立即记录,要么延迟出现(在第12至24小时之间),要么出现较晚(在第3天之后)。这42例伴有房室传导阻滞的下壁梗死(14例为不完全性,28例为完全性)与无传导阻滞的下壁梗死的不同之处在于:急性期临床症状的严重程度(35%伴有心力衰竭,19%伴有心源性休克);冠状动脉病变的严重程度(伴有房室传导阻滞的梗死患者中71.4%为三支血管病变,而无传导阻滞者为32%,p<0.02);右冠状动脉和左前降支动脉狭窄>70%的联合发生率;左心室功能的改变(53%伴有房室传导阻滞的患者射血分数低于30%);这些梗死的严重程度与房室传导阻滞无关(95%的病例中房室传导阻滞有所恢复),而是与冠状动脉疾病的严重程度、左心室功能障碍以及患者的高龄(72.3±8岁)有关。