Cenni E, Andollina A, Arciola C R, Cervellati M, Bertoni G, Cavedagna D, Pizzoferrato A
Laboratorio di Biocompatibilità dei Materiali da Impianto, Istituti Ortopedici Rizzoli-Bologna.
G Chir. 1994 Oct;15(10):422-8.
The antibiotic sensitivity of 19 Gram-positive bacterial strains (11 Staphylococcus aureus and 8 Staphylococcus epidermidis) and 16 Gram-negative strains (8 Escherichia coli and 8 Proteus species) was evaluated after contact with stainless steel and with some metals compounding the alloys used for prosthetic devices. The hypothesis was that the resistance to antibiotic therapy of infections associated with prosthetic implants is also due to a modification in the sensitivity of microorganisms. The results, compared to those obtained from control tests, showed only slight variations in the antibiotic sensitivity of the strains put in contact with the metals. In Gram-positive strains, after contact with metals, the increase in sensitivity occurred more frequently than the reduction. In Gram-negative strains, the decrease in sensitivity was more frequent than the increase. Proteus strains showed sensitivity variations more frequently than Escherichia coli strains. Titanium and nickel induced the highest number of variations, both in Gram-positive and Gram-negative strains.
评估了19株革兰氏阳性菌（11株金黄色葡萄球菌和8株表皮葡萄球菌）和16株革兰氏阴性菌（8株大肠杆菌和8株变形杆菌）与不锈钢以及构成假体装置所用合金的某些金属接触后的抗生素敏感性。假设是与假体植入相关感染对抗生素治疗的耐药性也归因于微生物敏感性的改变。与对照试验结果相比，与金属接触的菌株的抗生素敏感性仅显示出轻微变化。在革兰氏阳性菌株中，与金属接触后，敏感性增加比降低更频繁。在革兰氏阴性菌株中，敏感性降低比增加更频繁。变形杆菌菌株比大肠杆菌菌株更频繁地出现敏感性变化。钛和镍在革兰氏阳性和革兰氏阴性菌株中引起的变化数量最多。
