Portolés M, Refojo M F, Leong F L
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114.
J Biomed Mater Res. 1994 Mar;28(3):303-9. doi: 10.1002/jbm.820280304.
Bacterial adherence and colonization of biomedical prosthetic implants is one of the main causes for implant withdrawal. The abhesive (anti-adhesive) effect of poloxamer 407 on several Gram-positive and Gram-negative strains and the site of action of its effect have been investigated. Poloxamer 407 significantly inhibited 92-99% of Pseudomonas aeruginosa adherence to hydrophilic contact lenses (P < .05). This adherence inhibition was concentration-dependent. A reduction of about 50-60% was obtained for Staphylococcus strains, and 50-70% for Gram-negative strains other than Pseudomonas. The poloxamer seems to act on the bacteria surface, but not on the contact lens surface. Poloxamer 407 could potentially prevent implant-related infections and keratitis associated with contact lens wear, by inhibiting bacterial adherence onto the implant or contact lens surface.
生物医学假体植入物上的细菌黏附和定植是植入物取出的主要原因之一。已研究了泊洛沙姆407对几种革兰氏阳性菌和革兰氏阴性菌菌株的抗黏附作用及其作用位点。泊洛沙姆407显著抑制了92% - 99%的铜绿假单胞菌对亲水隐形眼镜的黏附（P <.05）。这种黏附抑制呈浓度依赖性。葡萄球菌菌株的黏附减少了约50% - 60%，除铜绿假单胞菌外的革兰氏阴性菌菌株的黏附减少了50% - 70%。泊洛沙姆似乎作用于细菌表面，而不是隐形眼镜表面。泊洛沙姆407可能通过抑制细菌在植入物或隐形眼镜表面的黏附，预防与植入物相关的感染以及与隐形眼镜佩戴相关的角膜炎。
