Christie J L
J Forensic Sci. 1976 Jul;21(3):671-9.
The possible hazards of local anesthetic agents in either moderate or large doses are not always fully appreciated. The toxic side effects following rapid systemic absorption may be the unsuspected cause of death following the clinical use of these substances. Data on 15 deaths after the administration of local anesthetic substances are summarized. Five case histories involving lidocaine (lignocaine, Xylocaine) and cocaine are presented in detail, including the results of toxicologic analysis. The literature relevant to similar fatalities is reviewed but contains little information relating to blood and tissue concentrations in fatal cases. It is hoped that this paper may assist in clarifying the cause of death in some previously problematic situations.
局部麻醉剂无论是中等剂量还是大剂量使用时，其潜在危害并非总能得到充分认识。这些物质临床应用后，快速全身吸收所致的毒性副作用可能是未被察觉的死亡原因。本文总结了15例局部麻醉剂给药后死亡的相关数据。详细介绍了5例涉及利多卡因（昔罗卡因，赛罗卡因）和可卡因的病例，包括毒理学分析结果。回顾了与类似死亡病例相关的文献，但关于致命病例血液和组织浓度的信息很少。希望本文有助于厘清一些此前存在问题的死亡原因。
