Alvarez Ferrero M M, Vree T B, Van Ewijk-Beneken Kolmer E W, Slooff T J
Institute of Orthopedics, Academic Hospital Nijmegen Sint Radboud, The Netherlands.
Biopharm Drug Dispos. 1994 Oct;15(7):599-608. doi: 10.1002/bdd.2510150707.
(i) The objective was to determine the range of bone levels of cefuroxime and flucloxacillin achieved after one intravenous (IV) administration of different dosages of cefuroxime and flucloxacillin. (ii) Six groups of five patients participated in the study. The first three groups (A-C) received respectively 1500 mg, 1000 mg, and 500 mg cefuroxime intravenously and the second three groups (D-F) received 2000 mg, 1500 mg, and 1000 mg flucloxacillin intravenously. (iii) Parenteral administration of cefuroxime and flucloxacillin resulted in measurable bone concentrations in all patients. (iv) Large inter-individual variation in bone concentration was observed. (v) The bone concentrations of IV cefuroxime were higher (1500 mg, p = 0.0057; 1000 mg, p = 0.0260) than those of flucloxacillin. The bone concentrations of cefuroxime and flucloxacillin were dose dependent.
（i）目的是确定静脉注射不同剂量的头孢呋辛和氟氯西林后，头孢呋辛和氟氯西林在骨组织中的浓度范围。（ii）六组，每组五名患者参与了该研究。前三组（A - C）分别静脉注射1500毫克、1000毫克和500毫克头孢呋辛，后三组（D - F）分别静脉注射2000毫克、1500毫克和1000毫克氟氯西林。（iii）头孢呋辛和氟氯西林的肠胃外给药在所有患者中均产生了可测量的骨浓度。（iv）观察到骨浓度存在较大的个体间差异。（v）静脉注射头孢呋辛的骨浓度高于氟氯西林（1500毫克，p = 0.0057；1000毫克，p = 0.0260）。头孢呋辛和氟氯西林的骨浓度呈剂量依赖性。
