Miksicek R J
Department of Pharmacological Sciences, State University of New York at Stony Brook 11794-8651.
Semin Cancer Biol. 1994 Oct;5(5):369-79.
Variant forms of steroid receptors that possess altered structure have been described in a number of human cancers. This is particularly true for tumors of the breast, which frequently contain a variety of defective estrogen receptors. Evidence for the existence of steroid receptor variants in human tumors is summarized along with what is known regarding the functional behavior of these aberrant receptors. This article also discusses the implications that steroid receptor variants have for the diagnosis and treatment of tumors of the breast and other human malignancies.
在多种人类癌症中已发现具有结构改变的类固醇受体变体形式。乳腺癌尤其如此，其经常含有多种有缺陷的雌激素受体。本文总结了人类肿瘤中类固醇受体变体存在的证据以及关于这些异常受体功能行为的已知情况。本文还讨论了类固醇受体变体对乳腺癌及其他人类恶性肿瘤的诊断和治疗的影响。
