Ito K, Iwabe K, Okai T, Kouda S, Tadokoro M, Isiko T
Department of Internal Medicine, Kawakita General Hospital, Tokyo.
Intern Med. 1994 Nov;33(11):710-3. doi: 10.2169/internalmedicine.33.710.
A 46-year-old man with chronic myelogenous leukemia (CML) was admitted to our hospital because of high fever. The chest radiographs showed bilateral groundglass-like infiltrates in the perihilar region. Transbronchial lung biopsy (TBLB) and autopsy revealed PAS-positive granular materials characteristic of pulmonary alveolar proteinosis (PAP). He had received interferon-alpha since the time of CML diagnosis. Busulfan had never been administered. Altered cell-mediated immunity was thought to be closely related to the development of PAP.
一名46岁的慢性粒细胞白血病（CML）男性因高热入住我院。胸部X线片显示双侧肺门周围区域有磨玻璃样浸润。经支气管肺活检（TBLB）及尸检发现符合肺泡蛋白沉积症（PAP）特征的PAS阳性颗粒物质。自诊断为CML以来，他一直在接受α干扰素治疗。从未使用过白消安。细胞介导免疫改变被认为与PAP的发生密切相关。
