Scheider A, Hintschich C, Dimitriou S
Augenklinik, Universität München.
Ophthalmologe. 1994 Dec;91(6):752-7.
Owing to its tight binding to protein, exudation of indocyanine green from subretinal new vessels would not normally be expected, but it has been demonstrated. We investigated 102 subretinal new vessels to find out how often exudation develops and to understand the reason for it. Exudation was found in 29 (28.4%) of the cases examined; 37 (36.6%) were stained, which means that these membranes became hyperfluorescent but not lighter than other, definitively non-exuding, structures on the fundus. In 26 (25.5%) no hyperfluorescence was seen in the late phase, and in 10, or 9.8%, neovascularization remained occult. The correlation of indocyanine green exudation with retinal blood or lipid deposits was significant (r = 0.77, p = 0.0001). Histological examinations showed a correlation of lipid deposits with a severe disintegration of retinal vessels. This finding, in combination with others, indicates that the exudation of indocyanine green reflects severe destruction of vessel walls, which does not seem to occur consistently in all neovascular membranes. The exudation of indocyanine green might be of prognostic value.
由于吲哚菁绿与蛋白质紧密结合，通常预计不会出现视网膜下新生血管渗漏吲哚菁绿的情况，但已有相关报道。我们对102例视网膜下新生血管进行了研究，以了解渗漏发生的频率及其原因。在29例（28.4%）受检病例中发现了渗漏；37例（36.6%）出现染色，这意味着这些膜呈现高荧光，但不比眼底其他明确无渗漏的结构更淡。26例（25.5%）在晚期未出现高荧光，10例（9.8%）新生血管未被发现。吲哚菁绿渗漏与视网膜血液或脂质沉积的相关性显著（r = 0.77，p = 0.0001）。组织学检查显示脂质沉积与视网膜血管严重破坏相关。这一发现与其他发现相结合，表明吲哚菁绿渗漏反映了血管壁的严重破坏，而这种情况似乎并非在所有新生血管膜中都会持续出现。吲哚菁绿渗漏可能具有预后价值。
