Sivkova N, Grigorov L, Kreissig I
Universitäts-Augenklinik, Medizinische Universität Plovdiv.
Ophthalmologe. 1994 Dec;91(6):820-3.
Various lymphocyte populations/subpopulations--Leu-4+ (CD3+), Leu-2+ (CD8+), CD4+/CD8+ ratio, Leu-14+ (CD22+), Leu-M5+ and HLA-DR+--were studied in 104 patients with basal cell carcinoma (BCC) of the eyelid in different TNM stages by Coulter EPICS flow cytometry preoperatively. For comparison, an age-matched control group of 60 clinically healthy individuals (30 male and 30 female) was used. The mean percentage of CD4+ T-lymphocytes was significantly decreased in T3N0M0 and T4N0M0 stages. In all TNM stages, especially in T3N0M0 and T4N0M0, the CD8+ T-lymphocyte subpopulation was significantly larger than in the control group. In all TNM stages the CD4+/CD8+ ratio was significantly lower than that of the control group. The degree of immune imbalance correlated directly with tumor size. The immunosuppression may be one factor in the development of BCC of the eyelid. Age- or genetic-related depression of cell-mediated immunity and increased exposure to carcinogenic agents, especially UV light, may play a part.
术前，通过库尔特EPICS流式细胞术对104例处于不同TNM分期的眼睑基底细胞癌（BCC）患者的多种淋巴细胞群体/亚群进行了研究，这些群体/亚群包括：Leu-4+(CD3+)、Leu-2+(CD8+)、CD4+/CD8+比值、Leu-14+(CD22+)、Leu-M5+和HLA-DR+。作为对照，使用了一个由60名临床健康个体（30名男性和30名女性）组成的年龄匹配对照组。在T3N0M0和T4N0M0期，CD4+T淋巴细胞的平均百分比显著降低。在所有TNM分期中，尤其是在T3N0M0和T4N0M0期，CD8+T淋巴细胞亚群显著大于对照组。在所有TNM分期中，CD4+/CD8+比值均显著低于对照组。免疫失衡程度与肿瘤大小直接相关。免疫抑制可能是眼睑基底细胞癌发生发展的一个因素。细胞介导免疫的年龄或遗传相关抑制以及致癌剂尤其是紫外线暴露增加可能起了一定作用。
