Duncan L, Alper S, Losick R
Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138.
Curr Opin Genet Dev. 1994 Oct;4(5):630-6. doi: 10.1016/0959-437x(94)90127-o.
Asymmetric cell division during the process of sporulation in the bacterium Bacillus subtilis generates dissimilar progeny that exhibit distinct programs of gene transcription. Recent work reveals a partner switching mechanism that governs the activity of the sporulation regulatory protein sigma F and that may be responsible for the establishment of cell type specific gene transcription.
在枯草芽孢杆菌的孢子形成过程中，不对称细胞分裂产生了不同的后代，这些后代表现出不同的基因转录程序。最近的研究揭示了一种伴侣切换机制，该机制控制着孢子形成调节蛋白sigma F的活性，并且可能负责细胞类型特异性基因转录的建立。
