对甲氧西林的耐药性表达
Expression of resistance to methicillin.
作者信息
Berger-Bächi B
机构信息
Dept of Medical Microbiology, University of Zürich, Switzerland.
出版信息
Trends Microbiol. 1994 Oct;2(10):389-93. doi: 10.1016/0966-842x(94)90617-3.
PMID:7850207
Abstract
Methicillin-resistant staphylococci have an additional low-affinity penicillin-binding protein, PBP2a (PBP2'), encoded by the mecA gene. The typical heterogeneity seen in the expression of resistance to methicillin and in levels of resistance depends on the concerted action of chromosomally encoded genes, including fem and aux, that are also present in the genome of susceptible staphylococci.
摘要
耐甲氧西林葡萄球菌有一种额外的低亲和力青霉素结合蛋白PBP2a（PBP2'），由mecA基因编码。耐甲氧西林表达和耐药水平中典型的异质性取决于染色体编码基因（包括fem和aux）的协同作用，这些基因在敏感葡萄球菌基因组中也存在。
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