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在甲氧西林存在的情况下生长的耐甲氧西林金黄色葡萄球菌菌株中产生的异常肽聚糖：青霉素结合蛋白2A在细胞壁合成中的功能作用。

Abnormal peptidoglycan produced in a methicillin-resistant strain of Staphylococcus aureus grown in the presence of methicillin: functional role for penicillin-binding protein 2A in cell wall synthesis.

作者信息

de Jonge B L, Tomasz A

机构信息

Rockefeller University, New York, New York 10021.

出版信息

Antimicrob Agents Chemother. 1993 Feb;37(2):342-6. doi: 10.1128/AAC.37.2.342.

DOI:10.1128/AAC.37.2.342
PMID:8452368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187665/
Abstract

Upon the addition of methicillin even at relatively low concentrations (5 mug/ml or 0.3% of the MIC) to the medium, methicillin-resistant staphylococci shift to the production of a new peptidoglycan with an abnormal muropeptide composition which may be the synthetic product of penicillin-binding protein 2A.

摘要

即便在培养基中加入相对低浓度的甲氧西林（5微克/毫升或最低抑菌浓度的0.3%），耐甲氧西林葡萄球菌也会转而产生一种具有异常肽聚糖组成的新型肽聚糖，这可能是青霉素结合蛋白2A的合成产物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be4/187665/4da08404759d/aac00024-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be4/187665/4da08404759d/aac00024-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be4/187665/4da08404759d/aac00024-0221-a.jpg

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本文引用的文献

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THE FINE STRUCTURE OF DIPLOCOCCUS PNEUMONIAE.肺炎双球菌的精细结构
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Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion.通过基因融合在耐甲氧西林金黄色葡萄球菌中诱导型青霉素靶蛋白的进化
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Two distinct transpeptidation reactions during murein synthesis in Escherichia coli.大肠杆菌细胞壁肽聚糖合成过程中的两种不同转肽反应。
采用培养方法和多重聚合酶链反应对人和动物临床分离株中的耐甲氧西林金黄色葡萄球菌进行调查。
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Spermine and oxacillin stress response on the cell wall synthesis and the global gene expression analysis in Methicillin-resistance Staphylococcus aureus.精胺和苯唑西林对耐甲氧西林金黄色葡萄球菌细胞壁合成及全局基因表达的应激反应分析
Genes Genomics. 2019 Jan;41(1):43-59. doi: 10.1007/s13258-018-0735-8. Epub 2018 Sep 18.
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