Ouellette M, Légaré D, Papadopoulou B
Service d'Infectiologie du CHUL, Université Laval, Québec, Canada.
Trends Microbiol. 1994 Oct;2(10):407-11. doi: 10.1016/0966-842x(94)90620-3.
Multidrug resistance in tumor cells is often caused by the increased efflux of a wide variety of drugs, mediated by P glycoprotein, a member of the superfamily of ATP-binding cassette (ABC) transporters. The genes encoding members of this superfamily have also been isolated from drug-resistant microorganisms, and the role of microbial ABC transporters in drug resistance is being investigated.
肿瘤细胞中的多药耐药性通常是由多种药物外排增加所致，这一过程由P糖蛋白介导，P糖蛋白是ATP结合盒（ABC）转运体超家族的成员之一。编码该超家族成员的基因也已从耐药微生物中分离出来，目前正在研究微生物ABC转运体在耐药性中的作用。
