Microbial multidrug-resistance ABC transporters.
作者信息
Ouellette M, Légaré D, Papadopoulou B
机构信息
Service d'Infectiologie du CHUL, Université Laval, Québec, Canada.
出版信息
Trends Microbiol. 1994 Oct;2(10):407-11. doi: 10.1016/0966-842x(94)90620-3.
PMID:7850210
Abstract
Multidrug resistance in tumor cells is often caused by the increased efflux of a wide variety of drugs, mediated by P glycoprotein, a member of the superfamily of ATP-binding cassette (ABC) transporters. The genes encoding members of this superfamily have also been isolated from drug-resistant microorganisms, and the role of microbial ABC transporters in drug resistance is being investigated.
摘要
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