多药耐药中的转运蛋白分子 - Suppr

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Transporter molecules in multidrug resistance.

作者信息

Scheper R J, Scheffer G L, Flens M J, van der Valk P, Broxterman H J, Izquierdo M A

机构信息

Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.

出版信息

Cytotechnology. 1996;19(3):187-90. doi: 10.1007/BF00744211.

DOI:10.1007/BF00744211

PMID:8862005

Abstract

摘要

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本文引用的文献

Unlocking vaults: organelles in search of a function.开启宝库：探寻功能的细胞器

Trends Cell Biol. 1991 Aug;1(2-3):47-50. doi: 10.1016/0962-8924(91)90088-q.

Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia.与Pgp/MDR1和MRP共同过度表达相关的功能性多药耐药表型以及对1-β-D-阿拉伯呋喃糖基胞嘧啶的敏感性可能预测急性髓系白血病的临床反应。

Clin Cancer Res. 1995 Jan;1(1):81-93.

Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia.主要穹窿转运蛋白肺耐药蛋白的过表达可预测急性髓系白血病的治疗结果。

Blood. 1996 Mar 15;87(6):2464-9.

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.人类多药耐药相关蛋白MRP是一种质膜药物外排泵。

Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8822-6. doi: 10.1073/pnas.91.19.8822.

Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.利用单克隆抗体对人多药耐药肿瘤细胞中多药耐药相关蛋白MRP进行免疫化学检测。

Cancer Res. 1994 Sep 1;54(17):4557-63.

Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma.原发性肝癌中多药耐药基因产物P-糖蛋白表达及细胞定位的免疫组织化学研究

Cancer. 1994 Jan 15;73(2):298-303. doi: 10.1002/1097-0142(19940115)73:2<298::aid-cncr2820730211>3.0.co;2-4.

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.编码多药耐药相关蛋白的基因过表达会导致ATP依赖性谷胱甘肽S-共轭物转运增加。

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):13033-7. doi: 10.1073/pnas.91.26.13033.

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.一种分子量为110,000的囊泡蛋白在非P-糖蛋白介导的多药耐药中的过表达

Cancer Res. 1993 Apr 1;53(7):1475-9.

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein.谷胱甘肽对过表达多药耐药相关蛋白的多药耐药人肺癌细胞系中药物转运的调节作用

Br J Cancer. 1995 Jul;72(1):82-9. doi: 10.1038/bjc.1995.281.

The drug resistance-related protein LRP is the human major vault protein.耐药相关蛋白LRP是人类主要穹窿蛋白。

Nat Med. 1995 Jun;1(6):578-82. doi: 10.1038/nm0695-578.

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