Cole S T
Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, Paris, France.
Trends Microbiol. 1994 Oct;2(10):411-5. doi: 10.1016/0966-842x(94)90621-1.
Tuberculosis has resurged during the past decade in many industrialized countries, and strains of Mycobacterium tuberculosis that are resistant to one or more of the main antituberculous drugs are emerging. The molecular basis of mycobacterial drug resistance is now beginning to be understood. Resistance derives from mutations in chromosomal genes leading to overproduction, alteration or loss of the drug target.
在过去十年中，结核病在许多工业化国家再度流行，并且对一种或多种主要抗结核药物耐药的结核分枝杆菌菌株不断出现。目前，人们开始了解分枝杆菌耐药性的分子基础。耐药性源于染色体基因突变，导致药物靶点过度产生、改变或缺失。
