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J Clin Pathol. 1981 Aug;34(8):927-9. doi: 10.1136/jcp.34.8.927.
2
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本文引用的文献

1
Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control programmes.分枝杆菌药敏检测技术的进展以及药敏检测在结核病控制项目中的应用。
Bull World Health Organ. 1969;41(1):21-43.
2
Some comparative aspects of rifampicin and isoniazid.利福平与异烟肼的一些比较方面。
Tubercle. 1968 Dec;49(4):367-76. doi: 10.1016/s0041-3879(68)80017-0.
3
In vitro activity of rifampin against the H37RV strain of Mycobacterium tuberculosis.利福平对结核分枝杆菌H37RV菌株的体外活性。
Am Rev Respir Dis. 1969 Mar;99(3):453-6. doi: 10.1164/arrd.1969.99.3.453.
4
Antituberculous activity of rifampin in vitro and in vivo and the concentrations attained in human blood.利福平在体外和体内的抗结核活性以及人体血液中达到的浓度。
Am Rev Respir Dis. 1968 Dec;98(6):923-32. doi: 10.1164/arrd.1968.98.6.923.
5
The antimycobacterial activity of rifampin.利福平的抗分枝杆菌活性。
Am Rev Respir Dis. 1968 Apr;97(4):713-4. doi: 10.1164/arrd.1968.97.4.713.
6
[Virulence of rifampicin-resistant tubercle bacilli for experimental animals (preliminary report)].[利福平耐药结核杆菌对实验动物的毒力（初步报告）]
Kekkaku. 1972 May;47(5):129-34.
7
The pattern of resistance development to rifampicin in Mycobacterium tuberculosis.结核分枝杆菌对利福平耐药性的发展模式。
Tubercle. 1972 Jun;53(2):111-7. doi: 10.1016/0041-3879(72)90027-x.
8
Rifampin: a semisynthetic derivative of rifamycin--a prototype for the future.
Annu Rev Microbiol. 1972;26:85-102. doi: 10.1146/annurev.mi.26.100172.000505.
9
Bactericidal activity in vitro and in the guinea-pig of isoniazid, rifampicin and ethambutol.异烟肼、利福平及乙胺丁醇在体外和豚鼠体内的杀菌活性。
Tubercle. 1976 Dec;57(4):251-8. doi: 10.1016/s0041-3879(76)80002-5.
10
Automatable radiometric detection of growth of Mycobacterium tuberculosis in selective media.在选择性培养基中对结核分枝杆菌生长进行可自动化的放射性检测。
Am Rev Respir Dis. 1977 Jun;115(6):1066-9. doi: 10.1164/arrd.1977.115.6.1066.

结核分枝杆菌菌株对利福平和异烟肼的耐药性。

Resistance to rifampicin and isoniazid in strains of Mycobacterium tuberculosis.

作者信息

Siddiqi S H, Aziz A, Reggiardo Z, Middlebrook G

出版信息

J Clin Pathol. 1981 Aug;34(8):927-9. doi: 10.1136/jcp.34.8.927.

DOI:10.1136/jcp.34.8.927
PMID:6792243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493987/
Abstract

Drug susceptibility studies on strains of Mycobacterium tuberculosis isolated from widely different populations of patients and tested by two different techniques indicated that all 55 strains resistant to rifampicin were also resistant to isoniazid, while many strains resistant to isoniazid were found to be susceptible to rifampicin. This observation, which has as yet unknown laboratory and clinical significance, may be particularly useful in management of patients. Further studies are called for to establish this relation.

摘要

对从广泛不同患者群体中分离出的结核分枝杆菌菌株进行药敏研究，并采用两种不同技术进行检测，结果表明，所有55株对利福平耐药的菌株也对异烟肼耐药，而许多对异烟肼耐药的菌株对利福平敏感。这一观察结果的实验室和临床意义尚不清楚，可能对患者管理特别有用。需要进一步研究来确定这种关系。