Hollifield J W, Kaiser A B, McGee Z A
JAMA. 1976 Sep 13;236(11):1264-6.
Gram-negative bacillary meningitis is a serious threat to patients with head trauma or altered immune systems, or those who have had neurosurgical procedures. The aminoglycoside antibiotics administered systemically and into the cerebrospinal fluid (CSF) have proved useful in the treatment of these infections. Intralumbar and parenteral gentamicin sulfate and tobramycin sulfate were administered to an acromegalic woman with Klebsiella meningitis. She had objective evidence of adhesive arachnoiditis and symptoms of polyradiculitis. Cessation of the aminoglycoside administration resulted in symptomatic improvement, and reinstitution of therapy caused a recurrence of neurologic symptoms. Polyradiculitis may be a complication of the intralumbar administration of aminoglycosides.
革兰氏阴性杆菌性脑膜炎对头部外伤患者、免疫系统改变的患者或接受过神经外科手术的患者构成严重威胁。已证明全身及向脑脊液（CSF）中注射氨基糖苷类抗生素对治疗这些感染有效。对一名患有克雷伯菌性脑膜炎的肢端肥大症女性患者进行了腰椎内及肠胃外注射硫酸庆大霉素和硫酸妥布霉素治疗。她有粘连性蛛网膜炎的客观证据及多神经根炎症状。停用氨基糖苷类药物治疗后症状有所改善，而重新开始治疗则导致神经症状复发。多神经根炎可能是腰椎内注射氨基糖苷类药物的一种并发症。
