肾脏中维生素D代谢的调节机制。

The mechanisms of regulation of vitamin D metabolism in the kidney.

作者信息

Suda T, Shinki T, Kurokawa K

机构信息

Showa University School of Dentistry, Tokyo, Japan.

出版信息

Curr Opin Nephrol Hypertens. 1994 Jan;3(1):59-64. doi: 10.1097/00041552-199401000-00008.

DOI:10.1097/00041552-199401000-00008

PMID:7850413

Abstract

Recently, the 24-hydroxylase enzyme of 25-hydroxyvitamin D3 was purified from rat and chick kidney, and its complementary DNA was cloned. The length of the rat 24-hydroxylase gene is about 15 kbp with 12 exons. Cloning of the 24-hydroxylase gene made it possible to examine the mechanism of regulation of vitamin D metabolism at the gene level. Expression of renal 24-hydroxylase mRNA is regulated by a balance of plasma parathyroid hormone and 1 alpha,25-dihydroxyvitamin D3 levels, whereas intestinal 24-hydroxylase mRNA is regulated mainly by plasma 1 alpha,25-dihydroxyvitamin D3. This article reviews recent progress in understanding the molecular aspects of vitamin D metabolism.

摘要

最近，从大鼠和鸡的肾脏中纯化出了25-羟基维生素D3的24-羟化酶，并克隆了其互补DNA。大鼠24-羟化酶基因的长度约为15千碱基对，有12个外显子。24-羟化酶基因的克隆使得在基因水平上研究维生素D代谢的调节机制成为可能。肾脏24-羟化酶mRNA的表达受血浆甲状旁腺激素和1α,25-二羟基维生素D3水平平衡的调节，而肠道24-羟化酶mRNA主要受血浆1α,25-二羟基维生素D3的调节。本文综述了在理解维生素D代谢分子方面的最新进展。