Haarmeier T, Altrup U, Speckmann E J
Institut für Physiologie der Universität Münster, FRG.
Brain Res. 1994 Nov 7;663(1):131-9. doi: 10.1016/0006-8993(94)90470-7.
The action of systemically applied GABA on voltage-dependent currents of the identified neurons B1-B4 in the buccal ganglia of Helix pomatia were investigated by conventional voltage clamp techniques. In the B4 neuron, superfusion with sodium-free solution or addition of tetrodotoxin to the bath medium abolished the voltage dependent inward current. This voltage dependent sodium current was reduced with GABA application. Muscimol exerted the same effect as GABA whereas administration of baclofen had no effect. Voltage-dependent sodium and calcium currents of the neurons B1-B3 remained unchanged with GABA application. It is concluded that GABA is capable of reducing voltage-dependent sodium currents of distinct neuronal individuals via a GABAA receptor-like structure.
采用传统电压钳技术研究了系统性应用γ-氨基丁酸（GABA）对苹果螺颊神经节中已鉴定的B1 - B4神经元电压依赖性电流的作用。在B4神经元中，用无钠溶液灌流或在浴液中添加河豚毒素可消除电压依赖性内向电流。这种电压依赖性钠电流在应用GABA后减小。蝇蕈醇与GABA发挥相同作用，而应用巴氯芬则无作用。应用GABA后，B1 - B3神经元的电压依赖性钠电流和钙电流保持不变。得出的结论是，GABA能够通过类似GABAA受体的结构降低不同神经元个体的电压依赖性钠电流。
