Nordin B E, Need A G, Horowitz M, Morris H A
Division of Clinical Biochemistry, University of Adelaide, Australia.
Clin Geriatr Med. 1994 Nov;10(4):625-46.
Fracture risk is adversely related to bone density, wherever it is measured. Women should be screened by bone densitometry around the time of the menopause and treated with calcium or hormones if the density is low. Women with vertebral compression should be treated with calcitriol if calcium absorption is low, with hormones if urine calcium is high, and with calcitriol and hormones if both abnormalities are present. It is uncertain whether newer treatments offer any advantages over this regimen. Vitamin D is indicated in household individuals or others with low levels of 25 OHD to prevent loss from secondary hyperparathyroidism and perhaps also to improve muscle power.
骨折风险与骨密度呈负相关,无论骨密度是在何处测量的。女性应在绝经前后接受骨密度测量筛查,若骨密度低则应补充钙剂或激素进行治疗。对于椎体压缩的女性,若钙吸收低,应使用骨化三醇治疗;若尿钙高,则应使用激素治疗;若两种异常情况都存在,则应使用骨化三醇和激素治疗。尚不确定新的治疗方法是否比该治疗方案有任何优势。对于25-羟维生素D水平低的居家个体或其他人,应补充维生素D以预防继发性甲状旁腺功能亢进导致的骨量流失,或许还能增强肌肉力量。