Streissguth A P, Barr H M, Sampson P D, Bookstein F L
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195.
Drug Alcohol Depend. 1994 Oct;36(2):89-99. doi: 10.1016/0376-8716(94)90090-6.
This report summarizes findings from a prospective longitudinal study of the effects of prenatal alcohol exposure on a birth cohort of 500 offspring selected from 1,529 consecutive pregnant women in prenatal care by mid-pregnancy at two representative community hospitals. Effects of prenatal alcohol observable on size measures at birth were insignificant after 8 months. Morphometric analysis of facial features identified effects only at the very highest alcohol exposure levels. By contrast, dose-dependent effects on neurobehavioral function from birth to 14 years have been established using partial least squares (PLS) methods jointly analysing multiple measures of both alcohol dose and outcome. Particularly salient effects included problems with attention, speed of information processing, and learning problems, especially arithmetic.
本报告总结了一项前瞻性纵向研究的结果，该研究旨在探讨产前酒精暴露对从两家代表性社区医院接受产前护理的1529名连续孕妇中选取的500名后代出生队列的影响。出生8个月后，产前酒精暴露对出生时的体型测量指标的可观察影响不显著。面部特征的形态计量分析仅在酒精暴露水平极高时才发现有影响。相比之下，使用偏最小二乘法（PLS）联合分析酒精剂量和结果的多项测量指标，已确定了从出生到14岁对神经行为功能的剂量依赖性影响。特别显著的影响包括注意力问题、信息处理速度问题和学习问题，尤其是算术方面的问题。
