Palmieri L, Ronca F, Malengo S, Bertelli A
Institute of Biological Chemistry, University of Pisa, Italy.
Int J Tissue React. 1994;16(3):121-9.
Susceptibility to oxidative stress is increased in erythrocytes of patients with beta-thalassaemia due to the free alpha-chain pool and to the excess of iron. We have investigated the effect of L-propionylcarnitine concentrations on oxidative stress determined by lactoperoxidase-hydrogen peroxide-iodide and by xanthine oxidase-acetaldehyde on erythrocytes of patients with beta-thalassaemia (major and intermedia). L-propionyl carnitine protects the erythrocytes from oxidative stress as measured by cell lysis. The protection is concentration-dependent. L-propionyl carnitine also stabilizes the cell membranes in which a latent peroxidative damage has been produced. These data suggest that L-propionyl carnitine may prove beneficial in protecting in vivo patients in which peroxidative damage of cell structure is increased as in the case of beta-thalassaemic patients.
由于游离α链池和铁过量，β地中海贫血患者红细胞对氧化应激的敏感性增加。我们研究了L-丙酰肉碱浓度对β地中海贫血（重型和中间型）患者红细胞氧化应激的影响，氧化应激通过乳过氧化物酶-过氧化氢-碘化物和黄嘌呤氧化酶-乙醛来测定。L-丙酰肉碱可保护红细胞免受氧化应激（通过细胞裂解来衡量）。这种保护作用具有浓度依赖性。L-丙酰肉碱还能稳定已产生潜在过氧化损伤的细胞膜。这些数据表明，L-丙酰肉碱可能对保护体内细胞结构过氧化损伤增加的患者有益，比如β地中海贫血患者。
