Colombo R, Lev A, Da Pozzo L F, Freschi M, Gallus G, Rigatti P
Department of Urology, Projecting and Development Unit, Scientific Institute H.S. Raffaele, Milan, Italy.
J Urol. 1995 Mar;153(3 Pt 2):959-63.
For some time hyperthermia, alone or in combination with radiotherapy or chemotherapy, has proved to be a promising method for treating several kinds of solid tumors. After intensive laboratory investigations a new device, based on a microwave source delivering local bladder hyperthermia together with intravesical mitomycin C chemotherapy has been clinically tested as a neoadjuvant approach in 44 patients suffering from superficial cancer of the bladder. The combined approach was administered on an outpatient basis without major complications and with acceptable local toxicity. Endoscopic and histological evaluations proved that combined local hyperthermia and chemotherapy can induce necrosis of transitional tumors. The overall response rate was 90.8%, with 70.4% complete and 20.4% partial, leaving 4 patients (9.2%) nonrespondent. Clinical and histological evaluations have confirmed the feasibility and safety of this combined treatment. Further multicentric studies have been initiated.
一段时间以来，热疗单独使用或与放疗或化疗联合使用，已被证明是治疗几种实体瘤的一种有前景的方法。经过深入的实验室研究，一种基于微波源的新设备，可在膀胱内注入丝裂霉素C化疗的同时进行局部膀胱热疗，已在44例浅表性膀胱癌患者中作为新辅助治疗方法进行了临床试验。这种联合治疗方法在门诊进行，没有严重并发症，局部毒性也可接受。内镜和组织学评估证明，局部热疗和化疗联合可诱导移行性肿瘤坏死。总缓解率为90.8%，其中完全缓解率为70.4%，部分缓解率为20.4%，4例患者（9.2%）无反应。临床和组织学评估证实了这种联合治疗的可行性和安全性。进一步的多中心研究已经启动。
