人类白细胞抗原A9与进行性系统性硬化症（硬皮病）的关联。
Association of HLA antigen a9 with progressive systemic sclerosis (scleroderma).
作者信息
Clements P J, Opelz G, Terasaki P I, Mickey M R, Furst D
出版信息
Tissue Antigens. 1978 Apr;11(4):357-61. doi: 10.1111/j.1399-0039.1978.tb01268.x.
Abstract
Upon evaluation of 40 subjects with progressive systemic sclerosis (PSS), a significant association of HLA antigens A9 and Aw24 (a subgroup of A9) was found with diffuse scleroderma. HLA-Aw23 (a second subgroup of A9) was also increased in the patients, however, this was not statistically significant. Diffuse scleroderma appears to be one of the few diseases that shows an association with the HLA-A locus.
摘要
在对40例进行性系统性硬化症（PSS）患者进行评估时，发现HLA抗原A9和Aw24（A9的一个亚组）与弥漫性硬皮病之间存在显著关联。患者中HLA-Aw23（A9的另一个亚组）也有所增加，然而，这在统计学上并不显著。弥漫性硬皮病似乎是少数与HLA-A位点相关的疾病之一。
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