HLA抗原与进行性系统性硬化症和硬斑病的关联。

Association of HLA antigens with progressive systemic sclerosis and morphea.

作者信息

Kühnl P, Sibrowski W, Boehm B O, Holzmann H, Sollberg S

机构信息

Universitäts-Krankenhaus Eppendorf, Chirurgische Klinik und Poliklinik, Hamburg, FRG.

出版信息

Tissue Antigens. 1989 Sep;34(3):207-9. doi: 10.1111/j.1399-0039.1989.tb01739.x.

DOI:10.1111/j.1399-0039.1989.tb01739.x

PMID:2595726

Abstract

The HLA phenotype frequencies of 40 patients with progressive systemic sclerosis (PSS) and 42 patients with morphea (sclerodermia circumscripta) indicate a weak, HLA-linked genetic predisposition of the affected individuals (70 female, 12 male). An "opposite" HLA A1, B8 (high immune response) vs A3, B7, DR2 (low immune response) constellation in PSS and morphea supports the clinical subdivision of scleroderma into these different nosological entities, and may serve as a differential diagnostic tool and prognostic marker.

摘要

40例进行性系统性硬化症（PSS）患者和42例硬斑病（局限性硬皮病）患者的HLA表型频率表明，受影响个体（70名女性，12名男性）存在与HLA相关的微弱遗传易感性。PSS和硬斑病中“HLA A1、B8（高免疫反应）与A3、B7、DR2（低免疫反应）”的相反组合支持将硬皮病临床细分为这些不同的疾病实体，并可作为鉴别诊断工具和预后标志物。