Kim J Y, Sohn J H, Youn D H
Department of Ophthalmology, College of Medicine, Seoul national University, Korea.
Korean J Ophthalmol. 1994 Dec;8(2):61-5. doi: 10.3341/kjo.1994.8.2.61.
We performed a randomized, prospective study to evaluate the effect of intraoperative, intracameral carbachol or acetylcholine on early postoperative intraocular pressure(IOP) after extracapsular cataract extraction(ECCE) and posterior chamber lens(PCL) implantation. Fifty-six eyes of 56 patients scheduled for routine ECCE and PCL implantation were randomly assigned into three groups: (1)carbachol infusion (19 eyes) (2) acetylcholine infusion (15 eyes) (3)balanced salt solution (BSS) infusion (control, 22 eyes). We compared the preoperative IOP, early postoperative IOP, postoperative 24 hours IOP and postoperative 1 week IOP. In the measurement of early postoperative IOP, IOP was measured at least twice at 3, 6 or 9 hours postoperatively. There was no significant difference in IOP between the three groups preoperatively, at postoperative 3 hours, and 1 week. At postoperative 6 hours, both the carbachol infusion group and acetylcholine infusion group were significantly different from the BSS infusion group. At postoperative 9 and 24 hours, only carbachol infusion group had a significant difference from BSS infusion group in suppression of postoperative IOP increase. Our results suggest that intraoperative, intracameral administration of carbachol or acetylcholine prevents early postoperative IOP increase, and that carbachol has a more lasting effect.
我们进行了一项随机前瞻性研究，以评估术中前房内注入卡巴胆碱或乙酰胆碱对白内障囊外摘除术（ECCE）及后房型人工晶状体（PCL）植入术后早期眼压（IOP）的影响。将56例计划行常规ECCE及PCL植入术患者的56只眼随机分为三组：（1）卡巴胆碱注入组（19只眼）；（2）乙酰胆碱注入组（15只眼）；（3）平衡盐溶液（BSS）注入组（对照组，22只眼）。我们比较了术前眼压、术后早期眼压、术后24小时眼压及术后1周眼压。在测量术后早期眼压时，于术后3、6或9小时至少测量两次眼压。三组术前、术后3小时及1周时眼压无显著差异。术后6小时，卡巴胆碱注入组和乙酰胆碱注入组与BSS注入组相比均有显著差异。术后9小时及24小时，仅卡巴胆碱注入组在抑制术后眼压升高方面与BSS注入组有显著差异。我们的结果表明，术中前房内给予卡巴胆碱或乙酰胆碱可预防术后早期眼压升高，且卡巴胆碱的作用更持久。
