Gupta A, Bansal R K, Grewal S P
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Cataract Refract Surg. 1992 Mar;18(2):166-9. doi: 10.1016/s0886-3350(13)80925-x.
Intraocular pressure (IOP) is known to increase after intracapsular cataract extraction, extracapsular cataract extraction (ECCE), and ECCE with intraocular lens (IOL) implantation. Many pharmacological agents have been used to prevent this IOP rise. We conducted a two-phase, randomized, prospective study to evaluate the natural behavior of IOP after cataract surgery and the effect of intraoperative intracameral carbachol on it. In phase 1, 102 cases were randomly assigned to three groups for recording IOP at 24, 48, or 72 hours after ECCE. The IOP at 24 (mean 20.3 mm Hg) and 48 hours (mean 22.3 mm Hg) was significantly higher than the preoperative IOP (mean 16.1 mm Hg); 26.3% of cases in group 1A (24 hours) and 44.1% of cases in group 1B (48 hours) had IOPs greater than or equal to 25 mm Hg. In phase II, intracameral carbachol (0.01%) was used in 30 cases of ECCE and in 30 cases of ECCE with IOL implantation. The IOP at 24 hours (mean 16.3 mm Hg) was not significantly higher than the preoperative IOP and only 11.6% of the cases had IOPs greater than or equal to 25 mm Hg. The mean IOP at 24 hours without carbachol was significantly higher than the mean IOP at 24 hours with it. There was no statistically significant difference between IOP in the two groups one week after surgery.
众所周知，囊内白内障摘除术、囊外白内障摘除术（ECCE）以及囊外白内障摘除联合人工晶状体（IOL）植入术后眼内压（IOP）会升高。许多药物已被用于预防这种IOP升高。我们进行了一项两阶段的随机前瞻性研究，以评估白内障手术后IOP的自然变化情况以及术中前房内注射卡巴胆碱对其的影响。在第一阶段，102例患者被随机分为三组，在ECCE术后24、48或72小时记录IOP。术后24小时（平均20.3 mmHg）和48小时（平均22.3 mmHg）的IOP显著高于术前IOP（平均16.1 mmHg）；1A组（24小时）26.3%的病例和1B组（48小时）44.1%的病例IOP大于或等于25 mmHg。在第二阶段，30例ECCE患者和30例ECCE联合IOL植入患者术中使用了前房内卡巴胆碱（0.01%）。术后24小时的IOP（平均16.3 mmHg）并不显著高于术前IOP，只有11.6%的病例IOP大于或等于25 mmHg。未使用卡巴胆碱时术后24小时的平均IOP显著高于使用卡巴胆碱时术后24小时的平均IOP。术后一周两组的IOP之间无统计学显著差异。
