Falcoff E, Giménez L A, Bernabó J G, Bottasso O
Unité INSERM Interférons et cytokines, Institut Curie, Paris, France.
Medicina (B Aires). 1994;54(3):265-71.
T lymphocytes from patients with visceral leishmaniasis treated in vitro with leishmania antigens are unable to proliferate and to produce gamma interferon. These patients have negative specific skin tests. Opposite results are obtained in patients with another clinical form of the disease named mucocutaneous leishmaniasis, in which both tests are positive. Nevertheless, patients with visceral leishmaniasis or mucocutaneous leishmaniasis, refractory to chemotherapy (antimonium complex), were cured when treated with antimonium in combination with gamma interferon, in spite of different immunological profiles. Different interpretative hypotheses of the reversion of chemoresistance induced by gamma interferon are discussed.
用利什曼原虫抗原体外处理的内脏利什曼病患者的T淋巴细胞无法增殖，也无法产生γ干扰素。这些患者的特异性皮肤试验呈阴性。在另一种名为皮肤黏膜利什曼病的临床疾病形式的患者中，得到了相反的结果，在这些患者中两种试验均呈阳性。然而，尽管免疫特征不同，但对化疗（锑复合物）难治的内脏利什曼病或皮肤黏膜利什曼病患者，在接受锑与γ干扰素联合治疗后均被治愈。讨论了关于γ干扰素诱导化疗耐药性逆转的不同解释性假说。
