Schimmer O, Drewello U
Institut für Botanik und Pharmazeutische Biologie der Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
Mutagenesis. 1994 Nov;9(6):547-51. doi: 10.1093/mutage/9.6.547.
9-Methoxytariacuripyrone, a nitro-aromatic compound isolated from Aristolochia brevipes showed strong mutagenic activity in strain TA98, TA100 and some YG strains of Salmonella typhimurium with and without S9 mix. Incubation with cytosol resulted in a heavy increase in mutagenicity. When incubated with microsomes the activity was dramatically decreased. The results are discussed in view of the enzymes possibly involved in activation and detoxification of the compound. The role of the basic structure on the mutagenicity mediated through the nitro group was also considered.
9-甲氧基塔里库瑞吡喃酮是一种从短管马兜铃中分离出的硝基芳香族化合物，在有或没有S9混合物的情况下，对鼠伤寒沙门氏菌的TA98、TA100菌株以及一些YG菌株均表现出很强的诱变活性。与胞质溶胶一起孵育会导致诱变性大幅增加。与微粒体一起孵育时，活性会显著降低。针对可能参与该化合物活化和解毒的酶对结果进行了讨论。还考虑了基本结构对通过硝基介导的诱变性的作用。
