Chakraborty A, Chatterjee M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, Italy.
Neoplasma. 1994;41(5):291-6.
Administration of vanadium as ammonium monovanadate (0.005 microgram/0.1 ml/mouse/day) was found to reduce the tumor cell proliferation in the host mice bearing Dalton's lymphoma. The high activity of gamma-glutamyl transpeptidase (GGT), a neoplastic marker, was seen in the host cells bearing lymphoma. Vanadium effectively prevented an increase in activity of gamma-glutamyl transpeptidase and maintained a sustained low activity of this enzyme. In addition, an improvement of the hematological aspects of the mice and almost fourfold elevation of erythropoietin (Epo) was obtained following vanadium treatment. This increase in Epo activity may play a vital role in regulating the growth of cellular neoplasia. The present study further confirms the antitumorigenic potential of vanadium in the control of tumor progression in lymphoma via modulating several factors involving erythropoiesis and may emerge as a new chemopreventive agent for the future.
发现以偏钒酸铵（0.005微克/0.1毫升/小鼠/天）形式给予钒可减少携带道尔顿淋巴瘤的宿主小鼠体内肿瘤细胞的增殖。γ-谷氨酰转肽酶（GGT）是一种肿瘤标志物，在携带淋巴瘤的宿主细胞中活性较高。钒有效地阻止了γ-谷氨酰转肽酶活性的增加，并使该酶维持持续的低活性。此外，钒处理后小鼠的血液学状况得到改善，促红细胞生成素（Epo）几乎升高了四倍。Epo活性的这种增加可能在调节细胞肿瘤的生长中起重要作用。本研究进一步证实了钒通过调节涉及红细胞生成的多种因素在控制淋巴瘤肿瘤进展方面的抗肿瘤潜力，并且可能成为未来一种新的化学预防剂。
