Bernasconi F, Gritti P, Ersettigh G, Galli F, Arienti S
Divisione di Ostetricia e Ginecologia, Regione Lombardia, USSL n. 63-Ospedale di Desio, Milano.
Minerva Ginecol. 1994 Nov;46(11):609-18.
In the period 9-1989/12-1991, 47 fertile women affected by genital HPV infection have been treated with i.m. systemic beta-interferon (3 x 10 x 6 UI every other day for 4 weeks). We have noticed 1 case of drop-out (2, 1%). At the short-medium follow-up (> or = 6 months), the therapy has proved to be probably and/or certainly efficacious in 74.4% of cases (35/47). In patients with condylomas in the cervical region, the less respondent part, we have noticed a reaction in 64.3% of cases; in those who have an extra-cervical or diffused HPV infection, in 89.4%. In the patients with complete follow-up, treated with supplementary DTC if necessary, the recovery ratio reached 92.5%. The i.m. systemic therapy with beta-IFN is efficacious in the treatment of genital HPV infections: it is well tolerated and offers the possibility of obtaining a useful "therapeutic integration" with the traditional destructive physical techniques of therapy.
在1989年9月至1991年12月期间，47名患有生殖器HPV感染的育龄妇女接受了肌肉注射全身性β-干扰素治疗（每隔一天注射3×10×6国际单位，共4周）。我们注意到1例退出治疗的情况（2.1%）。在短期至中期随访（≥6个月）中，治疗在74.4%的病例（35/47）中被证明可能和/或肯定有效。在宫颈区域尖锐湿疣患者（反应较差的部分）中，我们注意到64.3%的病例有反应；在宫颈外或弥漫性HPV感染患者中，反应率为89.4%。在完成随访且必要时接受补充二氯醋酸治疗的患者中，治愈率达到92.5%。肌肉注射全身性β-干扰素治疗生殖器HPV感染有效：耐受性良好，并提供了与传统破坏性物理治疗技术进行有效“治疗整合”的可能性。
