Facchini C, Eremita G A, Bernabei A
Istituto di Clinica Ostetricia e Ginecologica, Università degli Studi, Siena.
Minerva Ginecol. 1996 Sep;48(9):345-9.
230 women affected by HPV genital infection diagnosed by macroscopic examination, colposcopy and Pap test, were divided into two groups, of 95 and 135 people respectively, homogeneous for lesion localization and extension. The first group was treated with laser CO2 and the second group was treated with laser CO2 and intramuscular beta-interferon. We evaluated the side effects, the clinical results and the incidence of recurrences after 1, 6 and 12 months after the complete destruction of the lesions. At the first control, in both groups, we found no persistence of the lesions. At the second control after 6 months recurrences were present in 19 patients of the first group and in 7 patients of the second group. 51 recurrences were present after 12 months in the first group and 14 in the second group. The difference, evaluated with the chi 2 test, was found to be statistically significant (p < 0.01 after 6 months and p < 0.001 after 12 months).
230名经肉眼检查、阴道镜检查和巴氏试验诊断为HPV生殖器感染的女性被分为两组，分别为95人和135人，两组在病变定位和范围上具有同质性。第一组接受二氧化碳激光治疗，第二组接受二氧化碳激光和肌肉注射β-干扰素治疗。我们评估了病变完全消除后1个月、6个月和12个月的副作用、临床结果和复发率。在第一次复查时，两组均未发现病变持续存在。6个月后的第二次复查时，第一组有19例患者复发，第二组有7例患者复发。12个月后，第一组有51例复发，第二组有14例复发。经卡方检验评估，差异具有统计学意义（6个月后p<0.01，12个月后p<0.001）。
