Boegner F, Franke D, Altenkirch H, Stoltenburg G, Wagner M
Department of Neurology, Klinikum Steglitz, F.R.G.
Neurotoxicology. 1994 Fall;15(3):593-6.
Although their manufacture and use have been restricted or banned in Europe and the United States since the 1970s, polychlorinated biphenyls (PCBs) are still an ubiquitous environmental contaminant whose low-term effects are as yet not completely clear. Clinical case studies of patients with occupational exposure report cognitive impairment and peripheral neuropathy. In our defined nerve cell culture models in which we use pure neurons, pure glia and mixed cultures prepared from dorsal root ganglia of chick embryos we observed a neurotoxic effect after the application of a PCB compound (Clophen). It was only at higher concentrations that an additional gliatoxic effect could be observed.
尽管自20世纪70年代以来，多氯联苯（PCBs）在欧洲和美国的生产和使用已受到限制或被禁止，但它们仍是一种普遍存在的环境污染物，其长期影响尚未完全明确。职业暴露患者的临床病例研究报告了认知障碍和周围神经病变。在我们使用从鸡胚背根神经节制备的纯神经元、纯神经胶质细胞和混合培养物的特定神经细胞培养模型中，我们观察到在应用一种多氯联苯化合物（氯芬）后出现了神经毒性作用。只有在较高浓度时，才可以观察到额外的神经胶质毒性作用。
