Nagymajtényi L, Dési I, Schulz H
Department of Public Health, Albert-Szent-Györgyi Medical University, Szeged, Hungary.
Neurotoxicology. 1994 Fall;15(3):741-3.
Wistar rats were continuously treated with 7.0, 10.5, 14.0, and 28.0 mg/kg (1/100, 1/70, 1/50 and 1/25 LD50) of dimethoate per os including the pregnancy and lactation periods for three subsequent generations. The somatosensory, visual and auditory evoked brain potentials of male rats of each generation were registered at the age of 12-13 weeks with silver electrodes placed on the primary somatosensory, visual and auditory cortex. The measured parameters were the latency and duration of the evoked potentials. There were differences in the changes among the various evoked potentials in all of the generations. The strongest effect caused by dimethoate was seen in the case of the somatosensory evoked potentials compared to the control. The changes of the visual and auditory evoked potentials were milder. Comparing the changes of the evoked potentials of the three generations it was found that there were no significant changes between the data of the three populations.
将Wistar大鼠在包括妊娠和哺乳期的连续三代中，经口给予7.0、10.5、14.0和28.0毫克/千克（1/100、1/70、1/50和1/25 LD50）的乐果。在12 - 13周龄时，用银电极置于初级体感、视觉和听觉皮层，记录各代雄性大鼠的体感、视觉和听觉诱发脑电位。测量参数为诱发电位的潜伏期和持续时间。在所有代中，各种诱发电位的变化存在差异。与对照组相比，乐果对体感诱发电位的影响最为明显。视觉和听觉诱发电位的变化较轻微。比较三代诱发电位的变化发现，三组数据之间没有显著变化。
