Nagymajtényi L, Schulz H, Papp A, Dési I
Department of Public Health, Albert Szent-Györgyi Medical University, WHO Collaborating Centre for Chemical Safety, Szeged, Hungary.
Neurotoxicology. 1998 Aug-Oct;19(4-5):617-22.
Neurophysiological changes caused by parallel treatment with inorganic lead and dimethoate (a combination of possible health risk at population level) were investigated in different phases of the ontogenesis. Wistar rats were treated by gavage with lead (80.0 or 320.0 mg/kg); with dimethoate (7.0 or 28.0 mg/kg), or with their combination on days 5-15 of pregnancy, days 5-15 of pregnancy + days 2-28 of lactation (females of P generation), or days 5-15 of pregnancy + days 2-28 of lactation (females of P generation) + 8 weeks after weaning (males of F1 generation). Electrophysiological parameters (electrocorticogram, cortical evoked potentials) of the F1 male rats in the above groups were investigated at the age of 12 weeks. Both spontaneous and evoked electrophysiological phenomena showed dose-, treatment- and combination-dependent changes (e.g. significantly decreased mean amplitude and increased frequency of the electrocorticogram, lengthened latency and duration of the somatosensory, visual and auditory evoked potentials) which seemed to be more pronounced in the groups treated with the combination of lead and dimethoate than in the groups given lead or dimethoate alone. The results indicate that a simultaneous, pre- and postnatal exposure to the neurotoxicants, lead and dimethoate, considerably altered the functioning of the central nervous system.
在个体发育的不同阶段，研究了无机铅与乐果并行处理（这在人群层面可能存在健康风险组合）所引起的神经生理变化。用Wistar大鼠进行实验，在妊娠第5 - 15天、妊娠第5 - 15天 + 哺乳期第2 - 28天（P代雌性大鼠）或妊娠第5 - 15天 + 哺乳期第2 - 28天（P代雌性大鼠）+ 断奶后8周（F1代雄性大鼠），通过灌胃给予铅（80.0或320.0 mg/kg）、乐果（7.0或28.0 mg/kg）或它们的组合。在12周龄时，对上述组中的F1雄性大鼠的电生理参数（脑电图、皮层诱发电位）进行了研究。自发和诱发的电生理现象均显示出剂量、处理方式和组合依赖性变化（例如，脑电图的平均振幅显著降低、频率增加，体感、视觉和听觉诱发电位的潜伏期和持续时间延长），这些变化在铅和乐果组合处理组中似乎比单独给予铅或乐果的组更为明显。结果表明，在出生前和出生后同时暴露于神经毒物铅和乐果，会显著改变中枢神经系统的功能。
