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[切尔诺贝利反应堆灾难后儿童辐射诱发甲状腺癌的预防]

[Prophylaxis of radiation-induced thyroid cancers in children after the reactor catastrophy of Chernobyl].

作者信息

Reiners C

机构信息

Klinik und Poliklinik für Nuklear-medizin der Universität, Gesamthochschule, Essen, FRG.

出版信息

Nuklearmedizin. 1994 Dec;33(6):229-34.

PMID:7854918
Abstract

The incidence of thyroid cancer in children living in heavily contaminated regions some 100 km away from the Chernobyl nuclear power plant has increased significantly between 1989 and 1993. On the basis of this observation, preparations for iodine blockage of the thyroid in cases of reactor accidents should be made not only near but also far from nuclear power plants. The WHO recommendations on age-related dosage should be followed; the total iodide dose ranging between 15 and 150 mg daily may be split into several portions. In addition, prophylaxis of iodine-deficient goiters with 50-200 micrograms of iodide daily leads to a significant reduction of the risk of radiation-induced cancers. Consequent elimination of alimentary iodine deficiency should therefore be considered as the basis of precautions against health affects of reactor accidents. Thyroid hormones are indicated only in cases of thyroid enlargement, provided that lesions suspicious for malignancy have been definitely excluded. In the case of thyroid nodules in childhood, the indication for surgery and histological verification of the lesion has to be taken generously.

摘要

1989年至1993年间,居住在距离切尔诺贝利核电站约100公里的重污染地区的儿童甲状腺癌发病率显著上升。基于这一观察结果,不仅在核电站附近,而且在远离核电站的地方,都应做好反应堆事故时甲状腺碘阻断的准备工作。应遵循世界卫生组织关于按年龄划分剂量的建议;每日总碘剂量在15至150毫克之间,可分成几份服用。此外,每日服用50 - 200微克碘预防碘缺乏性甲状腺肿,可显著降低辐射诱发癌症的风险。因此,应将彻底消除膳食碘缺乏视为预防反应堆事故对健康影响的基础。仅在甲状腺肿大且已明确排除可疑恶性病变的情况下才使用甲状腺激素。对于儿童期甲状腺结节,手术指征及病变的组织学检查应放宽。

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