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甲状腺恶性肿瘤的药物治疗(作者译)

[Drug therapy of thyroid malignomas (author's transl)].

作者信息

Reinwein D

出版信息

Strahlentherapie. 1978 Jun;154(6):365-7.

PMID:78550
Abstract

We may recapitulate: Chemotherapy, first of all with adriamycin, has proved successful in thyroid cancer even after exhaustion of the therapeutic measures used so far. The combination of adriamycin with bleomycin and Velbe, corresponding to our preliminary experiences, seems to be superior to a monotherapy with adriamycin. The side effects remain absolutely tolerable. Hence follows concerning further procedure that chemotherapy has to be applied earlier than practiced up to now, i.e. as soon as criteria for metastasition are observed and/or if the primary treatment--operation and irradiation--does not satisfy. Cytostatic therapy apparently is the optimal treatment technique in medullar carcinoma. But it is necessary, moreover, to search for other effective combinations of chemotherapeutic agents, especially in the case of anaplastic carcinoma. Chemotherapy, assisted by thyroid hormone treatment, can certainly be improved further by a more severe assessment of the indication, by early application and, last not least, by better coordination with surgical and radiotherapeutical action.

摘要

我们可以总结如下

化疗,首先是使用阿霉素,已被证明在甲状腺癌治疗中取得成功,即使在目前所用治疗措施用尽之后。根据我们的初步经验,阿霉素与博来霉素和威猛(丙卡巴肼)联合使用似乎优于阿霉素单一疗法。副作用完全可以耐受。因此,关于进一步的治疗程序,化疗必须比目前更早应用,即在观察到转移标准和/或如果初始治疗(手术和放疗)不能令人满意时立即应用。细胞抑制疗法显然是髓样癌的最佳治疗技术。此外,有必要寻找其他有效的化疗药物组合,特别是在未分化癌的情况下。在甲状腺激素治疗的辅助下,化疗肯定可以通过更严格的适应症评估、早期应用以及最后但同样重要的是通过与手术和放射治疗行动更好地协调来进一步改进。

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1
[Drug therapy of thyroid malignomas (author's transl)].甲状腺恶性肿瘤的药物治疗(作者译)
Strahlentherapie. 1978 Jun;154(6):365-7.
2
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