Applegate B L
Kaiser Permanente Medical Center, Orange County, California.
Postgrad Med. 1995 Feb;97(2):121-6.
Many aspects of Kawasaki syndrome remain a mystery. The cause of the disease has eluded researchers, and its pathophysiology is a subject of much debate. However, the diagnostic features have been identified: A significant fever for at least 5 days, bilateral nonexudative conjunctivitis, erythema of the palms and soles, a polymorphic diffuse rash, cervical lymphadenopathy, and injection of the mouth and oropharynx. The recently instituted treatment protocol of high-dose aspirin with gamma globulin (Gamastan, Gammar) helps patients recover more quickly and with fewer potentially life-threatening sequelae than does aspirin alone.
川崎病的许多方面仍是个谜。该疾病的病因一直让研究人员捉摸不透，其病理生理学也是诸多争论的主题。然而，诊断特征已被确定：至少持续5天的高热、双侧非渗出性结膜炎、手掌和脚底红斑、多形性弥漫性皮疹、颈部淋巴结病以及口腔和口咽充血。与单独使用阿司匹林相比，最近制定的大剂量阿司匹林联合γ球蛋白（伽马抗人球蛋白、丙种球蛋白）的治疗方案能帮助患者更快康复，且减少潜在的危及生命的后遗症。
