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[头颈部原发性软组织肉瘤的治疗]

[Treatment of primary soft tissue sarcoma of the head and neck].

作者信息

Coustal B, Barthélémy I, Michelet V, Pinsolle J, Siberchicot F, Caix P, Michelet F X

机构信息

Services de Chirurgie Maxillo-Faciale, CHU de Bordeaux.

出版信息

Rev Stomatol Chir Maxillofac. 1994;95(6):423-6.

PMID:7855541
Abstract

Soft tissue sarcomas of the head and neck account for less than 1% of all malignant neoplasms in this region. A significantly increased risk of treatment failure is associated with high histologic grade, leading to an aggressive treatment. The medical records of 17 patients with soft tissue sarcomas of the head and neck were reviewed. They were divided into two groups according to age: 13 adults and 4 children. The former underwent wide surgical excision with postoperative radiotherapy in some cases and possibly chemotherapy. The 2 and 5 years survivals were 54% and 46% respectively. The latter, with rhabdomyosarcoma, underwent multimodality treatment (chemotherapy, surgery, radiotherapy). The 2 years survival was 50%. The mainstay of treatment of soft tissue sarcomas of the head and neck in adults remains surgery. Patients with incomplete resection or high grade tumour should receive more aggressive treatment (surgery and postoperative radiotherapy). The use of systemic chemotherapy has showed no statistically significant improvement in local control or survival. However, for rhabdomyosarcoma in children, chemotherapy is an essential part of treatment.

摘要

头颈部软组织肉瘤占该区域所有恶性肿瘤的比例不到1%。组织学高级别与治疗失败风险显著增加相关,从而需要积极治疗。回顾了17名头颈部软组织肉瘤患者的病历。根据年龄将他们分为两组:13名成人和4名儿童。前者接受了广泛手术切除,部分病例术后进行了放疗,可能还进行了化疗。2年和5年生存率分别为54%和46%。后者患有横纹肌肉瘤,接受了多模式治疗(化疗、手术、放疗)。2年生存率为50%。成人头颈部软组织肉瘤的主要治疗方法仍然是手术。切除不完全或肿瘤级别高的患者应接受更积极的治疗(手术和术后放疗)。全身化疗在局部控制或生存率方面未显示出统计学上的显著改善。然而,对于儿童横纹肌肉瘤,化疗是治疗的重要组成部分。

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