Yoshihara T, Shino A, Ishii T, Kawakami M
Department of Otolaryngology, Tokyo Women's Medical College, Japan.
Ultrastruct Pathol. 1994 Nov-Dec;18(6):553-8. doi: 10.3109/01913129409021898.
A case of salivary duct carcinoma of the parotid gland found in an 81-year-old man was studied by light microscopy, immunohistochemistry, and electron microscopy. Histologically, the tumor was composed of elongated cords of cells and ductal structure with desmoplastic stromal reaction. Tumor cell nests sometimes showed central comedonecrosis. Immunohistochemically, the tumor cells were positive for cytokeratin and epithelial membrane antigen, and they were negative for S-100 protein and muscle-specific actin. Electromicroscopically, two cell types were identified. The first cell type showed electron-lucent cytoplasm with scant organelles. The second type cell contained numerous mitochondria. Neither acinar nor myoepithelial cell differentiation was observed. These findings suggest that salivary duct carcinoma originates from the interlobular or excretory ducts.
对一名81岁男性腮腺涎腺导管癌病例进行了光镜、免疫组化和电镜研究。组织学上，肿瘤由细长的细胞索和导管结构组成，并伴有促纤维组织增生性间质反应。肿瘤细胞巢有时显示中央粉刺样坏死。免疫组化显示，肿瘤细胞细胞角蛋白和上皮膜抗原呈阳性，而S-100蛋白和肌肉特异性肌动蛋白呈阴性。电镜下，鉴定出两种细胞类型。第一种细胞类型显示细胞质电子密度低，细胞器稀少。第二种细胞含有大量线粒体。未观察到腺泡或肌上皮细胞分化。这些发现提示涎腺导管癌起源于小叶间导管或排泄管。
