[The significance of genetic markers in otosclerotic hearing loss].

Phenotypes HLA-A, HLA-B and HLA-C were determined in 85 patients with otosclerosis verified at surgery and in 113 clinically healthy subjects. The patients were divided into 2 groups: with family predisposition to otosclerosis (13 subjects) and without such (72 subjects). A tendency was established to more frequent occurrence of antigens A2, B12 versus less frequent of antigens B27, B40, Cw1 in patients compared to controls. It is concluded that at least one of the genes determining the resistance to otosclerosis exists in the HLA region, in binding groups B27, B40 and Cw1. It is suggested that genes predisposing to the disease (A2, B12) may be located at the same place.