克氏锥虫中的细胞色素P-450与药物代谢：苯巴比妥的作用
Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.
作者信息
Agosin M, Naquira C, Paulin J, Capdevila J
出版信息
Science. 1976 Oct 8;194(4261):195-7. doi: 10.1126/science.785602.
PMID:785602
Abstract
The epimastigotes of Trypanosoma cruzi hydroxylate drugs at substantial rates. The activity, which is of the mixed-function oxidase type, is increased by phenobarbital and is inhibited by CO, SKF 525-A, and metyrapone. The hydroxylation is paralleled by increases in free and membrane-bound ribosomes.
摘要
克氏锥虫的上鞭毛体以相当高的速率使药物羟基化。这种属于混合功能氧化酶类型的活性可被苯巴比妥增强，并被一氧化碳、SKF 525 - A和甲吡酮抑制。羟基化伴随着游离核糖体和膜结合核糖体数量的增加。
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