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克氏锥虫中的细胞色素P-450与药物代谢：苯巴比妥的作用

Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.

作者信息

Agosin M, Naquira C, Paulin J, Capdevila J

出版信息

Science. 1976 Oct 8;194(4261):195-7. doi: 10.1126/science.785602.

DOI:10.1126/science.785602
PMID:785602
Abstract

The epimastigotes of Trypanosoma cruzi hydroxylate drugs at substantial rates. The activity, which is of the mixed-function oxidase type, is increased by phenobarbital and is inhibited by CO, SKF 525-A, and metyrapone. The hydroxylation is paralleled by increases in free and membrane-bound ribosomes.

摘要

克氏锥虫的上鞭毛体以相当高的速率使药物羟基化。这种属于混合功能氧化酶类型的活性可被苯巴比妥增强，并被一氧化碳、SKF 525 - A和甲吡酮抑制。羟基化伴随着游离核糖体和膜结合核糖体数量的增加。

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引用本文的文献

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Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi.苯硝唑反应性代谢产物与克氏锥虫的核及动基体DNA、蛋白质和脂质的相互作用。
Experientia. 1988 Oct 15;44(10):880-1. doi: 10.1007/BF01941187.
2
Multiple forms of inducible drug-metabolizing enzymes: a reasonable mechanism by which any organism can cope with adversity.多种形式的诱导性药物代谢酶：一种任何生物体都能应对逆境的合理机制。
Mol Cell Biochem. 1979 Sep 28;27(1):27-46. doi: 10.1007/BF00849277.