La Bonnardière C, Lefèvre F, Charley B
I.N.R.A., Jouy-en-Josas, France.
Vet Immunol Immunopathol. 1994 Oct;43(1-3):29-36. doi: 10.1016/0165-2427(94)90117-1.
This paper reviews the current state of knowledge on porcine interferons (IFN). Three type I IFN subfamilies (IFN alpha, beta and omega) and one type II IFN (IFN gamma) have been identified in the porcine species. A list of the known porcine IFN genes and already produced recombinant proteins, as compiled from the literature, was included. Two major aspects of porcine IFN were discussed: (1) IFNs as host responses to infections, and (2) IFNs in pregnancy. The first part mainly focusses on the IFN production by virus-infected pigs and the nature of IFN alpha secreting leukocytes. The second part reviews recent data showing the secretion of two different IFNs by the pig embryo at the time of implantation. One striking finding was that a non-lymphoid tissue, namely the porcine trophoblast, was able to secrete high levels of IFN gamma. In addition, the expression of another, newly described, IFN gene was also shown in pig trophectoderm. This novel trophoblastic type I IFN differs from the others in size and sequence. Several hypotheses are discussed on the possible role(s) of porcine embryonic IFNs at the initial stages of gestation.
本文综述了关于猪干扰素（IFN）的当前知识状态。在猪中已鉴定出三个I型干扰素亚家族（IFNα、β和ω）和一个II型干扰素（IFNγ）。文中列出了从文献中汇编的已知猪IFN基因和已生产的重组蛋白。讨论了猪干扰素的两个主要方面：（1）干扰素作为宿主对感染的反应，以及（2）妊娠中的干扰素。第一部分主要关注病毒感染猪产生的干扰素以及分泌IFNα的白细胞的性质。第二部分综述了最近的数据，这些数据显示猪胚胎在着床时分泌两种不同的干扰素。一个显著的发现是，一种非淋巴组织，即猪滋养层，能够分泌高水平的IFNγ。此外，在猪滋养外胚层中也显示出另一种新描述的IFN基因的表达。这种新型的滋养层I型干扰素在大小和序列上与其他干扰素不同。文中讨论了关于猪胚胎干扰素在妊娠初期可能作用的几种假说。
