Jones R H, Sabiston D C
Surg Clin North Am. 1976 Aug;56(4):891-907. doi: 10.1016/s0039-6109(16)40985-0.
Pulmonary embolism is a common and often fatal postoperative complication. Dyspnea is the most common clinical manifestation in pulmonary embolism, and other signs are frequently inconsistent and often vague. The chest film and electrocardiogram may be helpful in excluding other cardiorespiratory diseases but they are frequently unreliable in establishing an objective diagnosis of pulmonary embolism. Documentation of a decreased arterial saturation provides suggestive evidence of pulmonary embolism. Lung scanning is a safe, sensitive procedure for the initial evaluation of symtoms suggestive of pulmonary embolism, and pulmonary arteriography may be necessary to confirm the diagnosis in certain patients. Anticoagulation is effective in the prevention and treatment of pulmonary embolism and proves successful in the vast majority of patients. Emboli that are not fatal gradually resolve in the pulmonary circulation. Vena caval interruption is occasionally beneficial in selected patients, especially those with septic emboli and cor pulmonale, but should only be performed when the indications are quite clear. Under certain selected circumstances pulmonary embolectomy may be indicated. Patients with massive embolism occluding more than one-half of the pulmonary arterial system and prooducing a markedly elevated pulmonary arterial pressure and severe hypoxemia may die in acute right heart failure. Intractable shock unresponsive to aggressive medical therapy in these patients represents an indication for pulmonary embolectomy. The hazards of these surgical procedures demand that a definite diagnosis of pulmonary embolism be made and a systematic approach to the diagnosis and treatment should be followed in all patients with the disorder.
肺栓塞是一种常见且往往致命的术后并发症。呼吸困难是肺栓塞最常见的临床表现,其他体征常常不一致且往往不明确。胸部X光片和心电图可能有助于排除其他心肺疾病,但在确立肺栓塞的客观诊断方面常常不可靠。动脉血氧饱和度降低的记录提供了肺栓塞的提示性证据。肺部扫描是对提示肺栓塞的症状进行初步评估的一种安全、敏感的检查方法,对于某些患者可能需要进行肺动脉造影以确诊。抗凝治疗在预防和治疗肺栓塞方面有效,并且在绝大多数患者中都能取得成功。非致命性栓子会在肺循环中逐渐溶解。腔静脉阻断偶尔对特定患者有益,尤其是那些患有感染性栓子和肺心病的患者,但仅在指征非常明确时才应进行。在某些特定情况下,可能需要进行肺栓子切除术。大量栓子阻塞超过一半的肺动脉系统并导致肺动脉压明显升高和严重低氧血症的患者可能死于急性右心衰竭。这些患者对积极的药物治疗无反应的顽固性休克是肺栓子切除术的指征。这些外科手术的风险要求对肺栓塞做出明确诊断,并且对于所有患有该疾病的患者都应遵循系统的诊断和治疗方法。