Vuong P N, Guettier C, Balaton A, Neveux Y, Houissa-Vuong S
Unité d'Anatomie et de Cytologie Pathologiques, Hôpital Saint-Michel, Paris.
Arch Anat Cytol Pathol. 1994;42(3-4):154-62.
The authors report a case of adenoid cystic (cylindromatous) carcinoma of the endocervical canal associated with an intraepithelial squamous cell carcinoma of the cervical os in a 60-year-old woman suffering from metrorrhagia. Immunohistochemical study demonstrated labeling of cylindromatous cells with anti-actin, anti-vimentin and anti-keratin antibodies. Ultrastructural study provided significant findings to confirm that the hyaline material surrounded by tumor cells was derived from the remnants of the lamina densa of the basement membrane of tumor lobules. These morphological data are similar to those observed in adenoid cystic carcinomas (cylindromas) of salivary glands. They support the hypothesis that adenoid cystic carcinoma of the cervix may develop from the multipotent reserve cells.
作者报告了一例60岁患有子宫出血的女性，其宫颈管腺样囊性（圆柱瘤样）癌合并宫颈外口上皮内鳞状细胞癌。免疫组织化学研究显示，圆柱瘤样细胞被抗肌动蛋白、抗波形蛋白和抗角蛋白抗体标记。超微结构研究提供了重要发现，证实肿瘤细胞周围的透明物质来源于肿瘤小叶基底膜致密层的残余物。这些形态学数据与在涎腺腺样囊性癌（圆柱瘤）中观察到的数据相似。它们支持宫颈腺样囊性癌可能起源于多能储备细胞的假说。
